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Furthermore, RNAi knockdown of -catenin and Wnt4 prevented supporting cell proliferation, suggesting that Wnt/-catenin signaling is required for at least the mitotic phase of regeneration (Alvarado et al., in vitro (Ku et al., Lgr5, Axin2, Klf5, Lef1 ) did not exhibit significant changes prior to proliferation

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Median PFS was significantly improved with BVd versus DVd (36.6 months vs 13.4 months

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